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KMID : 0388220140210060303
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Journal of the Korean Rheumatism Association
2014 Volume.21 No. 6 p.303 ~ p.310
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A Meta-analysis of the Diagnostic Value of Minor Salivary Gland Biopsy for Primary Sjogren’s Syndrome
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Lee Young-Ho
Song Gwan-Gyu
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Abstract
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Objective. The purpose of this study is to evaluate the diag-nostic performance of minor salivary gland biopsy (MSGB) for patients with primary Sjogren’s syndrome (pSS).
Methods. We have conducted a search from Medline, Embase, and Cochrane Library databases, and performed a meta-analysis on the diagnostic accuracy of MSGB in pSS patients.
Results. A total of eight studies, including 583 pSS and 627 non-pSS patients, were available for the meta-analysis. The pooled sensitivity and specificity of MSGB were 75.7% (95% confidence interval [CI], 72.0∼79.1) and 90.7% (88.1∼92.9), respectively. The positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 9.475 (4.051∼22.16), 0.266 (0.208∼0.340), and 38.92 (19.12∼72.21), respectively. The area under the curve was 0.901 and the Q* index was 0.902, indicating a high diag-nostic accuracy. Some between-study heterogeneity was found in the meta-analyses; however, there was no evi-dence of a threshold effect (Spearman correlation co-efficient=0.419; p=0.301). Meta-regression showed that the study quality, sample size, study design, and diagnostic cri-teria were not sources of heterogeneity, and subgroup meta-analyses did not change the overall diagnostic accuracy.
Conclusion. Our meta-analysis of published studies demon-strates that MSGB has a high diagnostic accuracy and may play an important role in the diagnosis of pSS.
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KEYWORD
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Primary Sjogren’s syndrome, Minor salivary gland biopsy, Diagnostic accuracy, Meta-analysis
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